Cajun Chicken and Shrimp Alfredo is a creamy, comforting dish with just the right kick of spice. It combines tender chicken and succulent shrimp seasoned with bold Cajun spices, all tossed in a rich, cheesy Alfredo sauce that’s perfect for pasta lovers. The blend of smoky heat and smooth, velvety sauce makes every bite a tasty treat.
I love making this dish when I want something cozy but flavorful. The Cajun seasoning adds a fun twist to traditional Alfredo, and cooking the chicken and shrimp separately lets me get that nice sear, locking in all the flavor. It’s one of those dishes that feels fancy but comes together pretty easily, which I always appreciate on busy weeknights.
My favorite way to enjoy it is with fettuccine or any thick pasta that can really hold onto the sauce. Sometimes, I toss in some fresh parsley or a squeeze of lemon just to brighten things up. It’s a meal that always feels special, whether I’m cooking for family or having friends over, and the leftovers are just as good the next day!
Key Ingredients & Substitutions
Cajun Seasoning: This spice mix brings the bold, zesty flavor to the chicken and shrimp. If you don’t have Cajun seasoning, a mix of paprika, garlic powder, cayenne pepper, and oregano works well.
Chicken and Shrimp: Using both gives the dish texture and taste variety. You can swap shrimp for scallops or just use chicken if preferred.
Heavy Cream & Parmesan: They make the Alfredo sauce rich and creamy. For a lighter version, try half-and-half or a milk-cheese combo, though the sauce won’t be as thick.
Fettuccine Pasta: This wide noodle holds the creamy sauce perfectly. You can substitute with linguine, tagliatelle, or even penne if you prefer.
How Can I Get Perfectly Cooked Cajun Chicken and Shrimp Every Time?
Cooking the chicken and shrimp right is key to the dish. Here’s how to nail it:
- Season both well with Cajun spices for a flavorful crust.
- Cook chicken first in a hot pan with oil until nicely browned and cooked through, about 5-6 minutes.
- Don’t overcrowd the pan to get that good sear; work in batches if needed.
- Next, cook shrimp quickly—just 2 minutes per side until pink and opaque—shrimp cook fast!
- Remove both from the pan before making the sauce to avoid overcooking.
This way, your chicken stays juicy, and the shrimp remain tender and not rubbery.
Equipment You’ll Need
- Large pot – for boiling the fettuccine pasta perfectly al dente.
- Large skillet or cast-iron pan – great for searing chicken and shrimp and making the sauce in one pan.
- Wooden spoon or silicone spatula – helps stir the sauce without scratching your pan.
- Whisk – perfect for mixing the cream and cheese smoothly into a creamy sauce.
- Sharp knife and cutting board – to slice the chicken and chop garlic and onions easily.
Flavor Variations & Add-Ins
- Swap shrimp for scallops for a different seafood twist that pairs beautifully with Cajun spices.
- Add sautéed bell peppers or spinach for a pop of color and extra veggies.
- Try smoked gouda or fontina instead of Parmesan for a creamier, richer sauce.
- Mix in a pinch of smoked paprika or chipotle powder for a smoky heat boost.
Cajun Chicken and Shrimp Alfredo
Ingredients You’ll Need:
For the Pasta and Protein:
- 8 oz fettuccine pasta
- 1 lb boneless, skinless chicken breasts, sliced into strips
- 1/2 lb medium shrimp, peeled and deveined
For the Seasoning and Sauce:
- 2 tbsp Cajun seasoning, divided
- 2 tbsp olive oil, divided
- 4 tbsp unsalted butter
- 4 cloves garlic, minced
- 1/2 cup onion, finely chopped
- 1 cup mushrooms, sliced (optional)
- 2 cups heavy cream
- 1 cup freshly grated Parmesan cheese
- Salt and black pepper, to taste
- Fresh parsley, chopped (for garnish)
- Lemon wedges (optional)
Time Needed
This recipe takes about 10 minutes to prep and 20-25 minutes to cook, making it perfect for a quick, delicious weeknight meal.
Step-by-Step Instructions:
1. Cook the Pasta:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside.
2. Prepare the Chicken:
Season the chicken strips with 1 tablespoon of Cajun seasoning. Heat 1 tablespoon olive oil in a large skillet over medium-high heat. Add chicken and cook until browned and cooked through, about 5-6 minutes. Remove from skillet and set aside.
3. Cook the Shrimp:
Season the shrimp with the remaining 1 tablespoon of Cajun seasoning. In the same skillet, add remaining tablespoon olive oil. Cook shrimp about 2 minutes per side until pink and opaque. Remove from skillet and set aside with the chicken.
4. Make the Alfredo Sauce:
In the skillet, melt butter over medium heat. Add minced garlic, chopped onions, and mushrooms if using. Sauté for 3-4 minutes until fragrant and onions translucent.
Slowly pour in the heavy cream and bring to a gentle simmer. Let cook 3-5 minutes until slightly thickened. Gradually whisk in Parmesan cheese until melted and smooth. Season with salt and pepper.
5. Combine Everything:
Add cooked pasta to the skillet and toss to coat with Alfredo sauce. Return chicken and shrimp to the pan and gently fold them in. Cook for 2 more minutes to warm through.
6. Serve:
Garnish with chopped fresh parsley and serve immediately. A squeeze of fresh lemon juice adds a nice touch if you like a hint of brightness.
Can I Use Frozen Shrimp for This Recipe?
Absolutely! Just make sure to fully thaw the shrimp before cooking. Thaw them overnight in the refrigerator or quickly under cold running water, then pat dry to avoid extra moisture in the pan.
Can I Make Cajun Chicken and Shrimp Alfredo Ahead of Time?
Yes, you can prepare the sauce and cook the chicken and shrimp in advance. Store them separately in airtight containers in the fridge for up to 2 days. Reheat gently on the stove, adding a splash of cream or milk if the sauce has thickened too much.
What Is the Best Way to Store Leftovers?
Keep leftovers in an airtight container in the fridge for up to 3 days. When reheating, warm it slowly on the stove or microwave, stirring occasionally to heat evenly and prevent the sauce from separating.
Can I Substitute the Pasta or Protein in This Dish?
Definitely! You can swap fettuccine with linguine, tagliatelle, or penne. For protein, chicken and shrimp can be replaced with scallops, just chicken, or even tofu for a vegetarian twist—just adjust cooking times accordingly.
